Prediction of hip fracture risk in men using blood markers

In the elderly, a decrease in hormones during aging accelerates the osteoclast activity of osteoclasts, resulting in a higher rate of bone turnover and increased fracture rates in the elderly. Thus, the regulatory mechanism of osteoclast differentiation plays an important role in the pathogenesis of osteoporosis (


Chemokines or chemotactic cytokines are small signaling cytokines that are important involved in these processes. CXCL9 and CXCL10 are specifically involved in different bone regulatory pathways.


Despite promising experimental data, no human studies have confirmed an association between these chemokines and the risk of osteoporosis or fracture.

Therefore, in this study, we assessed whether CXCL9 and CXCL10 levels were increased in human serum samples of older adults with hip fractures in a prospective population-based study of Chinese adults. National elderly in Singapore or not.

Is osteoporosis worse for men?

The study included 55 men and 119 women who suffered hip fractures an average of 6.3 years after the blood was drawn. Participants were matched individually to a control to see who didn’t have a hip fracture.

Investigators observed higher blood chemokine CXCL9 levels in pre-fracture blood samples of men with subsequent hip fractures compared with non-fractured controls. No such difference was seen in women (2 Trusted Source
CXCL9 Prediction of hip fracture risk in a prospective cohort of Chinese men-A matched controlled study.

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This unexpected difference in outcomes between men and women in the study could be explained by the fact that changes in sex hormone levels during aging may affect CXCL9 levels and effects differently. in older men and women.

The new findings open up an exciting possibility that early interventions targeting CXCL9 or CXCL9-CXCR3 signaling may be beneficial in preventing hip fractures in older men.

Presenter :

  1. Risk factors for hip fracture in older men: The Men Fracture Study (MrOS) – (
  2. CXCL9 Prediction of Meteorological Hip Fracture risk in a prospective cohort of Chinese men-A matched controlled study- (

Source: Medindia

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