The team of scientists and researchers at the University of California, Riverside (UCR) led by Qixuan Wang, a mathematical biologist at UCR, set out to explore how this works and say with reporters in an organization press release. The findings of this study were published in
.
Hair is a fascinating subject for scientific research, as it has a root system that grows strand-by-strand while on the surface of the skin. However, when the hair grows outside the structure, the cells inside have died a lot and no longer need nutrients and are pushed out due to many dead cells accumulating at the root. Again, the key to an effect is to know the cause (
).
In most animals, hair growth and shedding are regulated by the changing seasons and are more easily adjusted over time. So it seems odd that people don’t have good control over the limited amount of hair they shed after reaching a certain age. Therefore, the researchers sought to understand the factors that influence hair loss and what can be done to prevent it.
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As millions of people worldwide search for ways to slow or stop baldness, a unique chemical has emerged – stem cells.
Using stem cells in the process of growing and growing hair
Scientists seem to solve all problems using stem cells. Stem cells can turn into any other cell type. However, when it comes to hair-related injuries, the problem is that it always stems from them.
The adaptability of stem cells makes them useful in repairing damaged tissues or organs. Study co-author Qixuan Wang, PhD, of UCR, said: “In science fiction where characters quickly heal, the idea is that stem cells enable it.
Beneath the base of each hair is a hair follicle that nourishes the hair cells as they grow. Follicles are filled with stem cells, which can quickly direct them to perform certain tasks.
The hair follicles originate from the first and second layers of the skin (epidermis and dermis).2✔ ✔Trusted Source
Hair follicles
Go to source). In the human body, stem cells act as a response to injury; however, studies have shown that the TGF-β protein in those stem cells works inside the hair follicles, even without injury.
“In real life, our new research helps us better understand stem cell behavior, so we can control it and promote wound healing,” says Wang.
How does TGF-β Control Hair Loss and Promote Hair Regrowth?
TGF-β is a small protein that acts extracellularly and is involved in cell signaling. Interestingly, TGF-β is the only chemical involved in the activation and termination of cell division in hair follicles.
As with most chemicals in the human body, it is the amount of the chemical that makes the difference. In limited amounts, TGF-β activates cell division. When overproduced, it causes cells to die.
“TGF-β has two opposing roles. It helps to activate certain hair follicle cells to give rise to new life, and then, it helps to regulate apoptosis, the cell death process,” Wang said. speak.
As with many chemicals, it is the quantity that makes the difference. If the cell produces a certain amount of TGF-β, it triggers cell division. Too much of it induces apoptosis.
No one is entirely sure why the follicles destroy themselves. Some theories suggest that it is a genetic trait from animals that shed their fur to survive the hot summer temperatures or try to camouflage themselves.
“Even if the hair follicle self-destructs, it never destroys its reservoir of stem cells. When the surviving stem cells receive the signal to regenerate, they divide, creating new growth,” says Wang. make new cells and grow into a new hair follicle.
They still need to determine exactly how TGF-β triggers cell division to activate follicular stem cells and stimulate hair growth. It’s not just healing bald but also in the proper healing of hair growth after the wound has healed.
Discovered to promote hair regrowth
To understand the underlying mechanism of hair follicle cell fate control, scientists have developed a new probabilistic Boolean model of epithelial cell gene regulation dynamics. The model was first obtained from the literature, and then purified using single-cell RNA sequencing data.
This model predicts that these points could guide future experiments and promote hair growth and prevent hair loss:
The relationship between the topological structure of the gene regulatory network and the mechanism of cell fate regulation has been revealed. A discrete spatial model is fitted, illustrating how TGF-β and TNF cooperate in initiating and driving the apoptosis wave during catagen.
“There is a possibility that our work could provide something to help people who are facing a variety of problems,” said Wang.
The truth about baldness is that by focusing on these unique regenerative cells, the researchers hope to promote complete wound healing with hair regrowth and regrowth, and the ability to adapt. Their properties make them useful in repairing damaged tissues or organs and curing baldness.
Presenter :
- Hair loss: Overview – (https://www.aad.org/public/diseases/hair-loss/causes/fall-out)
- Hair follicles – (https://my.clevelandclinic.org/health/body/23435-hair-follicle#)
- A probabilistic Boolean model of hair follicle cell fate regulation by TGF-β – (https://www.cell.com/biophysj/fulltext/S0006-3495(22)00428-3)
Source: Medindia
