“The accident killed 17 people, injured 22, the injured were taken to hospital,” state broadcaster CCTV quoted the local government as saying.
The “major road traffic accident” took place just before 1 a.m. (17:00 GMT) in Nanchang district, the newspaper reported.
“The cause of the accident is under intensive investigation,” CCTV added.
About an hour after the news broke, the Nanchang district traffic police issued travel advice to drivers saying the area was experiencing “foggy weather”.
“Poor driving visibility, low visibility, easy to cause traffic accidents,” it said.
“Pay attention to the fog lights… slow down, drive carefully, keep a safe distance from the vehicle in front, avoid pedestrians, don’t change lanes and overtake,” it added. Road accidents are common in China due to the lack of strict safety controls.
Last month, one person died in a traffic jam on a highway in central China that involved hundreds of vehicles and was caused by poor visibility in the fog.
And in September, 27 passengers died after a bus took them to quarantine facilities in the southwest Guizhou Province upside down on the highway.